wegovy medication interactions

Wegovy Drug Interactions: What to Combine and Not to Combine With

, reviewed by
 – Updated January 6, 2023
, reviewed by
 – Updated January 6, 2023
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Table of Contents

Weight loss can take a long time. Sometimes, it can take years, so it’s important to know how the drug you’re using for weight loss interacts with other medications you’re taking.

Wegovy differs from other drugs in the way of its administration (it is an injectable), but it can interact with medicines in any form (tablets, capsules, injections, etc.). Let’s find out what are Wegovy medication interactions to avoid possible adverse reactions from drug interactions.

Drug interactions can be:

  • Dangerous;
  • Serious;
  • Moderate;

There are currently no data on dangerous interactions between Wegovy and other drugs. There are serious and moderate interactions between Wegovy and some drugs for diabetes. If you have diabetes and take these medications, consult the specialist before taking Wegovy. What other medicines can you take with the drug?

Wegovy and Prozac interaction

Doctors prescribe Prozac to treat depression, panic attacks, obsessive-compulsive disorder, and some eating disorders. It is an antidepressant. Beneficial to the nervous system, Prozac reduces the desire to eat, which may contribute to weight loss. Wegovy has a different mechanism of action so that you can use it during Prozac treatment. Check with your doctor if you can combine these drugs, considering individual characteristics.

Wegovy and Lexapro interaction

Lexapro is an antidepressant, which active ingredient is escitalopram. You can use the drug to treat depression and anxiety disorders. If anxiety makes you want to eat, reducing anxiety with Lexapro will help curb your appetite and lose weight. But unlike Wegovy, this drug is not for weight loss. There are no interactions between Lexapro and Wegovy. Inform your doctor if you plan to take these medicines at the same time.

Wegovy and Levothyroxine interaction

They use Levothyroxine to treat thyroid diseases, replacing the hormone it produces with hypothyroidism. Will it help in weight loss? If a metabolic disorder due to a thyroid gland malfunction leads to excess weight, metabolism normalisation can lead to weight loss. Wegovy and Levothyroxine belong to different drug classes, and no interactions were found between them.

Wegovy and Covid vaccine interaction

Covid-19 vaccines do not interact with most prescription and over-the-counter drugs, so that you can get vaccinated during Wegovy treatment. If you have any questions, discuss them with a doctor, who will give helpful advice and dispel your doubts. Currently, there is no data on the interaction between Covid-19 vaccines and Wegovy.

Wegovy and anesthesia interaction

Does Wegovy reduce the effectiveness of anesthesia? It seems not. The drug allows you to control hunger and acts on completely different systems in the body. This makes it possible to combine Wegovy treatment with anesthesia, if required. There are no data that this can cause any adverse effects or reduce the effectiveness of pain relief.

Wegovy and Zoloft interaction

Zoloft is an antidepressant. You can use it for depression, OCD, panic disorder, PTSD and social phobia. The drug does not affect weight, although one of its side effects is loss of appetite, which can cause weight loss. However, the action of Zoloft differs from that of Wegovy, and you can combine these drugs after consulting a doctor.

Wegovy and Vyvanse interaction

Doctors prescribe Vyvanse, which active ingredient is lisdexamfetamine, for attention deficit hyperactivity disorder. It is a stimulant of the nervous system, increasing the activity of hormones such as dopamine and norepinephrine in the brain. It increases attention and improves behaviour. There is no information on the interaction between Wegovy and Vyvanse. If you plan to take these medicines together, consult a doctor.

Wegovy and B12 interaction

B12 is a vital vitamin for maintaining health. It affects bone strength and eye health, prevents anemia and cardiovascular diseases, improves the condition of hair and nails, fights depression, etc. If you have a deficit of B12, you can take it while you are on Wegovy, as no data confirms their interaction. But consultation with a specialist will not be redundant.


Like any medicine, Wegovy may interact with other drugs. For example, it interacts with diabetes drugs prescribed to control blood glucose.
Wegovy can also lower blood sugar levels, so taking it with these drugs is undesirable and can cause dangerous side effects. At the same time, Wegovy does not interact with most other medicines. But before taking any of them during obesity treatment, consult a doctor.

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