Does Phentermine Cause Depression

Does Phentermine Cause Depression? Is It Possible, and How to Avoid It?

, reviewed by
 – Updated May 8, 2023
, reviewed by
 – Updated May 8, 2023
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Mood swings are one of the reported side effects of Phentermine. According to the package insert, Phentermine causes depression or euphoria.

The thing is that it stimulates the release of neurotransmitters, which increase leads to feelings of joy and fun. Increased activity or decreased amount of these substances can result in depression.

Stimulating neurotransmitters with Phentermine also leads to a drop in estrogen in women and testosterone in men, which are essential for a normal emotional state. It is also one of the possible causes of depression when taking Phentermine. Estrogen increases the amount of serotonin (the happiness hormone), so mood swings and worsening happen when it decreases.

These emotions increase several times if you experience anger, sadness, or despair. The same happens at the initial stage of depression or when you have recently had it. The reason is that Phentermine not only increases energy levels but also enhances emotional reactions. Sometimes, this happens suddenly and manifests especially strongly.

Why is it so? Changing levels of substances in the body are due to incorrect dosage. Sudden stopping the drug after a long use leads to the same result. Follow the doctor’s prescriptions regarding the doses of Phentermine and the duration of its use.

What antidepressant can I take with Phentermine?

If the drug has affected your mood, you are depressed, and you want to correct the situation with other medications, ask your doctor what antidepressant you can take with Phentermine.

According to the manufacturer’s information, Phentermine has varied interactions with different types of antidepressants: early, old and new:

  • MAOIs are also for the treatment of Parkinson’s disease. They increase blood pressure. So, in the case of prolonged use of Phentermine, they increase the risk of a hypertensive crisis. You shouldn’t use them simultaneously for more than 14 days.
  • TCAs (tricyclic antidepressants) can also increase blood pressure, as can PTZs (phenothiazines). On the contrary, SSRIs have few side effects. SSRIs increase serotonin levels, which may decrease when taking Phentermine. But you can use them together only as directed by your doctor.


Phentermine affects the number of hormones in the body, which can lead not only to weight loss but also to a change in an emotional state. If you notice mood swings, consult your doctor. If you suspect that you are suffering from one of Phentermine side effects, depression, don’t start taking antidepressants on your own!

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