Phentermine and Didrex

Didrex vs Phentermine. Which of These Drugs Helps People Lose Weight Faster?

, reviewed by
 – Updated May 8, 2023
, reviewed by
 – Updated May 8, 2023
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Table of Contents

There are many medicines for weight loss. How to choose the one that’s right for you? In this article, we will compare two popular drugs: Didrex and Phentermine.

Active substanceBenzphetaminePhentermine hydrochloride
Drug classCNS stimulant and appetite suppressant
Intended forAdults with a body mass index of 30 or moreAdults with a body mass index (BMI) of 30 or more. Or for those with a BMI ≥27 and diagnosed with type 2 diabetes, high cholesterol, or hypertension
Generic availabilityYesYes
Approved for useNo more than 12 weeks12 weeks, with a possibility of extension
Common body effectBoth drugs stimulate the CNS to increase heart rate and suppress appetite
Specific effectIncreased metabolismIncreased energy level
Dosage formTabletsTablets and capsules
Doses usedAvailable in a dosage of 50 mg. A maximum daily dose is 150 mg or three tablets (in the morning, afternoon and evening)Available in dosages of 8 mg, 15 mg, 18.75 mg, 30 mg and 37.5 mg. A maximum daily dose is 37,5 mg.
Possible side effects
  • Tachycardia
  • Headache;
  • Nausea
  • Diarrhea
  • Anxiety
  • Dizziness;
  • Sweating
  • Tremor
  •  Insomnia
  • Dry mouth
  • Insomnia
  • Constipation
  • Headache;
  • Fatigue
  • Menstrual cycle changes
  • Hair loss
  • Nausea
  • Abdominal pain
  • Rash
  • Pimples
  • Diarrhea
  •  Dry mouth
WarningsThey can increase blood pressure and heart rate
ContraindicationsIt is not suitable for people with:

  • Arterial hypertension;
  • Heart arrhythmia;
  • Thyroid diseases;
  • Glaucoma.
It is not suitable for people with:

  • Cardiovascular diseases;
  • Thyroid diseases;
  • Glaucoma.
Special conditionsDon’t take Didrex if you used another weight loss drug within the previous 12 months.In rare cases, if you don’t follow the dosing regimen, taking Phentermine can lead to a stroke.

Don’t take these two drugs at the same time.

Which of these drugs is more effective?

Studies have shown that people who took Didrex lost an average of 1 pound or 0.45 kg per week. That is, within 12 weeks (the maximum approved period for the drug’s use), the average weight loss will be 12 pounds or 5.44 kg.

In another study, using Phentermine for 14 weeks resulted in an average weight loss of about 7.2 kg.

So, you can consider Phentermine a more effective weight loss remedy than Didrex.


Didrex and Phentermine work about the same.

Their differences include:

  • Active ingredients;
  • Dosage forms;
  • Possible side effects;
  • Treatment duration;
  • Some other characteristics;
  • Dosage. Phentermine has a broader range of available dosages, which is more convenient for consumers.

However, only a doctor must decide which weight loss product to use for each individual, considering all available information.

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