semaglutide vs metformin

What is the Difference Between Semaglutide and Metformin?

, reviewed by
 – Updated May 12, 2023
, reviewed by
 – Updated May 12, 2023
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Semaglutide and Metformin are effective medications used to reduce weight and in diabetes of 2nd type therapy. Very often, people with problems with being overweight and high blood sugar try to compare these two types of medicines. Many people are trying to figure out which drug is more effective – Semaglutide vs Metformin and which one suits them best.

To resolve such a dilemma, it is necessary to recall once again the key features of Semaglutide and Metformin. In particular, we need to identify the pharmacodynamics of each drug. Pharmacodynamics explains what biochemical reactions the drug produces in the body solve your problem.

The pharmacodynamics of Semaglutide and Metformin differ significantly. These drugs have different effects on glycemia, insulin secretion and the work of the gastrointestinal tract. These two drugs lead people to weight loss but in different ways.

To better understand how these medicines affect the body, and finally get a reply to the question “Is Metformin a Semaglutide?”, you can compare the list of effects that each drug can produce.

How does Metformin influence the system:

  • Lessens insulin resistance, so cells are able to absorb and use sugar more effectively,
  • Lowers sugar absorption in intestines so that less sugar gets into the bloodstream,
  • Lowers the amount of sugar the liver produces,
  • Delays the absorption of carbohydrates in the intestine,
  • Stimulates glycogen synthesis by acting on glycogen synthase,
  • Increases the transport capacity of all types of membrane glucose transporters,
  • Has a beneficial effect on lipid metabolism,
  • Reduces the content of total cholesterol.

How does Semaglutide influence the system:

  • Regulates the concentration of glucose in the blood,
  • Stimulates insulin secretion,
  • Suppresses the secretion of glucagon,
  • Reduces overall body weight,
  • Reduces the mass of adipose tissue,
  • Enhances satiety signals and weakens hunger signals,
  • Improves the digestion processes,
  • Relieves cravings for food,
  • Reduces the insulin resistance of the body.

In the listed features, you may have noticed that there is a real difference in Metformin vs Semaglutide effects on insulin secretion and gluconeogenesis. As a typical remedy to combat high blood sugar, Semaglutide stimulates insulin secretion. In turn, Metformin does not increase insulin secretion but improves the body’s sensitivity to insulin.

Also, both drugs have different effects on appetite and brain receptors responsible for the feeling of hunger. Semaglutide has an anorexic effect, affecting the receptors that create a feeling of satiety. In turn, Metformin does not suppress appetite. This drug helps to lose excess weight by regulating the mass of fat in the cells. It will saturate your body with energy for daily activity from food and the available resources of adipose tissue.


Both medicines are effective in weight loss and therapy for diabetes of the 2nd type. Semaglutide is an effective appetite suppressant that can restore insulin secretion and influence the brain receptors responsible for the feeling of hunger.

Metformin suits better people who can’t benefit from diet and physical exercises in their weight management. This medication restores biochemical reactions responsible for glucose genesis and its further transportation in the bloodstream. It reduces the release of glucose into the blood by the liver and makes the body more sensitive to insulin. This complex of biochemical reactions affects the body’s excess weight. While taking Metformin, people slowly lose weight or keep it without gaining extra volume in adipose tissues.

Some people wonder can you take Semaglutide with Metformine in order to benefit from both actions. The best answer is to consult with your doctor, but their concomitant use is indeed possible.

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