You torture yourself with hunger and physical loads, while the scales indicator stands still or shows a weight gain? You can’t get rid of the haunting hunger and desire to eat something? Then you should try Qsymia.
Phentermine-Topiramate extended release (Qsymia) in Australia is a modern combination drug, which acts gently and helps people confront their increased appetite and effectively deal with extra kgs.
Qsymia treatment enhances the feeling of satiety, which leads to a decrease in food intake and a gradual weight loss. Just one Qsymia pill – and you will be spared for the day of:
- constant feeling of hunger;
- frequent desire to eat something;
- increased appetite and overeating.
Indications for use
Qsymia is a central-action anorexigenic drug and is used to treat alimentary obesity in adults and the elderly. The drug is designed specifically for those obese people, in whom conservative weight loss methods do not help to lose weight.
Qsymia is a prescription drug, and patients should pass additional diagnostic examination before they start taking it. These tests help find out current health condition and identify the cause of obesity.
The anorexigenic drug is administered to obese people aged 18 years and over, whose BMI is:
- 30 kg/m2 or higher
- 27 kg/m2 to 29.9 kg/m2 in the presence of risk factors, such as hyperlipidemia, type 2 diabetes mellitus.
Mechanism of action and dosage form
Qsymia is a combined medication, which contains two active substances:
Phentermine (appetite suppressant)
Affects brain areas that control appetite:
- stimulates saturation center
- depresses hunger center
Affects the activity of two neurotransmitters:
- enhances the action of GABA
- decreases the action of glutamate
Qsymia is supplied on the pharmaceutical market in the form of extended-release gelatin capsules. Oral capsules are available in four different dosages:
- 3.75 mg
- 7.5 mg
- 11.25 mg
- 15 mg
- 23 mg
- 46 mg
- 69 mg
- 92 mg
Advantages of Phentermine
- Reduces appetite
- Increases satiety
Advantages of Topiramate
- Reduces cravings for sweets
- Enhances the effect of Phentermine
The dosing regimen for Qsymia is the same for all patients – one Qsymia capsule once a day, in the morning, without regard to meals.
- During the first 2 weeks, patients take one Qsymia 3.75 mg/23 mg capsule.
- At the beginning of the third week (on the 15th day), the dose of the drug is increased. At this point, patients take one Qsymia 7.5 mg/46 mg capsule over the next 12 weeks.
In 12 weeks after increasing the dose of the drug, evaluation of obtained results should be conducted. If the patient fails to reduce his weight by at least 3% of the original weight during this time, the course of this anorexigenic drug stops, or the therapeutic dose is increased and the therapy continues.
If the treatment continues, the dosing regimen is as follows:
- Within 2 weeks, the patient takes one Qsymia 11.25 mg/69 mg capsule.
- In 2 weeks, the drug dose is increased to the maximum – one Qsymia 15 mg/92 mg capsule daily.
In 12 weeks after the use of the maximum dose, the treatment efficacy is analyzed. The drug shall be discontinued when the patient’s body mass does not decrease by at least 5% of the baseline weigh. If weight loss is more than 5%, the drug is continued until the desired result is achieved.
For a successful and sustainable weight loss:
- Take capsules every day at the same time.
- Combine Qsymia with adequate exercise and low-calorie diet.
Possible side effects and Precautions
As a rule, low doses of the drug are well tolerated and do not cause significant discomfort. The emergence of adverse reactions is most often associated with exceeding the maximum daily dose, or individual patient’s peculiarities.
- Most frequent side effects are headache, insomnia, constipation, dizziness, fatigue, nasopharyngitis, changes in libido. As the treatment continues, these effects disappear.
- In some patients, Qsymia can significantly raise blood pressure and accelerate heart rate, disturb vision clarity, enhance irritability.
At the same time, the drug may promote serious side effects, such as metabolic acidosis, depression, and anxiety. In patients, who suffer from type 2 diabetes, Qsymia administration can cause a sharp decrease in blood glucose levels.
The drug is teratogenic and may cause congenital fetal malformations. Before a woman begins taking this anorectic drug, she is advised to take a pregnancy test and choose effective contraceptives.
Abolition of the drug should be gradual. Patients begin taking Qsymia capsule every other day, for a minimum of one to two weeks to a complete withdrawal of the drug. Abrupt discontinuation may contribute to seizures.
Contraindications and drug interactions
Qsymia is contraindicated in the following conditions and diseases:
- acute myopia, glaucoma;
- severe hepatic and renal impairment;
- pregnancy and breastfeeding period.
The drug is not recommended to be combined with MAO inhibitors, drugs that depress the activity of the central nervous system (hypnotics, sedatives) and alcohol.
Combined use of Qsymia with antiepileptic drugs requires careful dose adjustment, because it can provoke hyperammonemia (increase in ammonium ions in the plasma).
- Qsymia can enhance the effect of water pills (Chlorothiazide, Furosemide), which can lead to hypokalemia.
- If the anorectic drug needs to be combined with a diuretic, it is recommended to split their administration with 3-hour intervals.
The drug use in compliance with all recommendations and with the account take of the body peculiarities will help obese person to lose weight faster and more effectively, than he would through conservative weight-loss methods only.
Are you tired of debilitating diets and trainings? Stop wasting your time. Start losing weight today. Choose Qsymia.
I have been taking Duromine 15mg for 3.5 years to maintain my weigh which is affected by Lipedema. It has been life changing for me and I am very lucky I have a doctor who is an expert on Lipedema and the use of Duromine.