Ozempic Vs Januvia: what is more effective

Ozempic Vs Januvia. What Medicine is More Effective?

, reviewed by
 β€“ Updated May 8, 2023
, reviewed by
 β€“ Updated May 8, 2023
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Weight loss can be easily compromised by a variety of factors, and it might be very difficult to achieve the desired result without using medical aid. It is especially relevant for people suffering from different health conditions.

Luckily, the pharmaceutical industry offers new medications and people wonder which is better and whether you can combine the use of several medications to achieve higher results. Today, we discuss Ozempic and Januvia. Let’s check out how these medications differ from each other and whether they have any similarities.

Β Januvia vs Ozempic: the main differences

Ozempic is a separate drug used as monotherapy for type 2 diabetes. It lowers blood sugar level by simulating the action of the natural hormone GLP-1, which promotes insulin secretion.

Januvia β€” DDP-4 inhibitor. This medicine is an adjunct to other medicines in treating type 2 diabetes.

Active substanceSemaglutideSitagliptin
Dosage formSubcutaneous injection solutionOral tablets
Drug classIncretin mimeticsDipeptidyl peptidase 4 inhibitors
Main side effects
  • Low blood sugar (people with type 2 diabetes);
  • Headache;
  • Diarrhea, constipation;
  • Heartburn;
  • Nausea, vomiting;
  • Abdominal pain;
  • Dizziness.
  • Upper respiratory tract infection;
  • Cold in the head;
  • Sore throat;
  • Headache.
Other brand namesRybelsus, WegovyNo
Generic availabilityNoNo
Half-life period168 hours12 hours
Interaction with other drugs245. Of these, 2 serious, 222 moderate and 21 minor ones275. Of these, 2 serious, 251 moderate and 24 minor ones
Interaction with alcoholIt is recommended to exclude alcohol or drink it in minimal doses completely: 1 dose per day for women and 2 doses for men (1 dose is 5 ounces of wine or 12 ounces of beer or 1.5 ounces of distilled spirits)
Caution with the following diseases
  • Suicidal behaviour and thoughts;
  • Family and/or personal history of thyroid cancer;
  • Endocrine neoplasia (tumours in the glands);
  • Diabetic ketoacidosis;
  • Retinopathy;
  • Pancreatitis;
  • Hypoglycemia
  • Pancreatitis;
  • Kidney dysfunction;
  • High levels of triglycerides in the blood;
  • History of alcoholism.


Can Januvia and Ozempic be used together? Yes, you can use these two drugs together in complex therapy.

Of course, they have different effectiveness. See a study that lasted 56 weeks. During the study, scientists compared Ozempic and Januvia in combination with metformin. In this combination, Ozempic was almost twice as effective as Januvia.


Both drugs are for treating people with type 2 diabetes, but they belong to different drug classes.

Ozempic is a separate drug. They use Januvia in complex treatment with other medications.

Ozempic is available as injector pens. Januvia is an oral tablet.

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