ozempic vs metermin

Metformin and Ozempic for Weight Loss: What You Need to Know

, reviewed by
 – Updated January 12, 2023
, reviewed by
 – Updated January 12, 2023
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Let us compare these drugs and examine their pros and cons.

If we compare Ozempic vs Metformin for weight loss, the first drug will win this battle.

Ozempic is the only injectable drug with such a high proven efficacy.

According to research, these medications can help people lose weight, and here are the average results they can achieve:

  • Ozempic – 17.4 % from their original weight in 14 months.
  • Metformin – 5.6 % from their initial weight in 6 months.

The drugs were not compared directly, and the duration of the studies was different. However, one can see that Ozempic (Semaglutide) helps to cope with a much more significant amount of body fat.

Is it possible to combine these pharmaceutical products, and how do they affect weight management? Let us try to figure it out.

Using Ozempic and Metformin together for weight loss

Doctors can outachieve when treating overweight or obese people using Ozempic and Metformin combination therapy. However, one cannot argue that this treatment method suits each situation.

There is strong evidence that these drugs do not interact. However, only a doctor can answer the question: Can you take Ozempic and Metformin together?

When combining these medications, you should pay attention to the following:

  • The doses of the drugs increase gradually.
  • Metformin tablets are taken orally three times a day or once before dinner in the case of long-acting tablets.
  • Ozempic injection solution is injected into subcutaneous adipose tissue once a week.

Application of Ozempic and Metformin together and side effects

These drugs have a different mechanism of action but a similar profile of side effects. Each of them individually can potentially harm other parts of your gastrointestinal tract. Therefore, with combination therapy, adverse reactions from the stomach or intestines often appear or worsen.

Ozempic vs Metformin for PCOS

There were no clinical trials to compare the effects of Ozempic or Metformin in PCOS.

These medications are not licensed or approved to treat PCOS. However, they can:

  • Improve hormonal balance.
  • Reduce the percentage of body fat.
  • Improve insulin sensitivity.

The listed effects may improve the symptoms of PCOS.


There are many options to treat overweight or obesity. Ozempic and Metformin combined therapy can benefit weight loss, but only if a doctor controls this process.

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