Cymbalta vs Phentermine

Cymbalta and Phentermine: Similarities and Differences

, reviewed by
 – Updated December 1, 2022
, reviewed by
 – Updated December 1, 2022
Table of Contents
Table of Contents

Cymbalta is a relatively new drug from the group of antidepressants, which therapeutic effects have not yet been fully studied. Phentermine is a long-used medicine for obesity, which is known throughout the world.

In this article, we will consider the drugs Cymbalta and Phentermine and discuss their similarities, differences and therapeutic actions.

Comparison table.

IndicationsOverweight, obesityDepression, anxiety disorders, neuropathic pain with diabetes
Drug classAnorexicsSNRI antidepressants
Available dosage formsTablets, capsulesEnteric-coated capsules
World market launch19592004
Status in AustraliaApproved by the TGAApproved by the TGA
Active ingredientPhentermineDuloxetine
Age restrictionsFrom 12 yearsFrom 18 years


Important information!

You can use any medicine for purposes not specified in this article or its package leaflet. Only a doctor must decide whether you can take prescription drugs and what dosage regimen you should follow.


Do not take these medicines together. When you combine them, too much serotonin can accumulate in the body (serotonin syndrome). Symptoms of this dangerous condition include:

  1. Mental fog.
  2. Disorientation.
  3. Headache.
  4. Tremor.
  5. Excessive sweat.
  6. Fast heartbeat.
  7. Anxiety.
  8. Irritability.

Cymbalta and Phentermine for weight loss

Why to compare these drugs if they have different indications?

The thing is that many antidepressants affect body weight. For example, tricyclic antidepressants usually cause weight gain. Those who take SNRI antidepressants, including Duloxetine, often report a reduction in body fat.

Here’s what we found out:

Regarding Phentermine, it is a legal obesity drug doctors officially prescribe. 62% of people on treatment report weight loss of at least 10% in 12 weeks.

So, in the battle of Cymbalta vs Phentermine, Phentermine is the undisputed winner.


Only a doctor can decide which medicine to use to treat your condition. Regarding the treatment of overweight or obesity, it would be better to use drugs such as Phentermine.

Cymbalta can cause weight loss of a few kilograms, but no large-scale clinical studies have confirmed the effectiveness of this treatment.

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