Ibuprofen taken with Phentermine

Can I Take Ibuprofen With Phentermine?

, reviewed by
 – Updated May 8, 2023
, reviewed by
 – Updated May 8, 2023
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While fighting obesity, some people who use Phentermine pills suffer from headaches and pain of different etiologies. In such cases, the first idea that appears in mind is to take painkillers. For a certain group of people, headache represents the most common side effect while taking Phentermine. Therefore a question became popular – can I take Ibuprofen with Phentermine?

Currently, there are no clinically confirmed interactions between Ibuprofen and Phentermine. However, this does not mean that they cannot exist. The difficulty in determining the interaction lies in the fact that both drugs produce active work in different body systems.

Phentermine dissolves in the gastrointestinal tract, getting into the liver and circulatory system, after which it turns out to be in the brain’s neural connections affecting neurotransmitters responsible for feeling full.

Ibuprofen is also dissolved in the gastrointestinal tract. Later it enters the circulatory system and acts on the enzyme Cyclooxygenase (COX), which usually increases the sensitivity of sensory neurons during inflammatory processes. Ibuprofen reduces the activity of COX, thereby reducing the load on sensory neurons after that, the person ceases to feel pain.

Ibuprofen & Phentermine: what to be aware of?

Do all previously described facts mean that you can take Phentermine and Ibuprofen together freely and without fear of consequences? Of course, no, because before making these drugs combo, you must be sure in your system. Before making such a choice get advice from your doctor.

Combining Phentermine and Ibuprofen can lead to increased blood pressure and heart rate. If you must take Ibuprofen and Phentermine simultaneously, adjusting the dose and carefully monitoring blood pressure are necessary.

Who should avoid taking Phentermine and Ibuprofen together

  1. People with a hypersensitive system to Ibuprofen and its ingredients;
  2. Those who previously suffered from:
  • Kidney disease;
  • Hypertension;
  • Vascular pathologies;
  • Gastrointestinal disorders;
  • Bronchial asthma;
  • Allergic diseases.

In all these cases, the combined effect of Phentermine and Ibuprofen can create excessive stress on the blood vessels and nerves.


In short, answering the question “Can you take Ibuprofen with Phentermine” is simple. There are no direct contraindications for taking Phentermine and Ibuprofen, but simultaneous administration of these drugs can represent a significant risk for people who previously suffered from vessel problems. Do not take these medicines together without your healthcare provider’s recommendation based on monitoring your health’s current state.

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