Bydureon and Ozempic. Similarities and Differences

Bydureon Vs Ozempic. Similarities and Differences

, reviewed by
 – Updated May 3, 2023
, reviewed by
 – Updated May 3, 2023
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Table of Contents

Ozempic and Bydureon are used to improve glycemic control in adults with type 2 diabetes when combined with diet and exercise. In their action, both drugs are glucagon-like peptide 1 receptor agonists.

Comparison tables for Bydureon and Ozempic

Active substanceSemaglutideExenatide
ActionIt promotes the production of insulin in the body, which lowers blood sugar levels
DosageA starting dose of 0.25 mg once a week. You can increase it to 0.5 and even up to 1 mg if required.A dose of 2 mg once a week before or after food
Same side effects
  • Nausea;
  • Vomiting;
  • Diarrhea;
  • Constipation.
Different side effects
  • Abdominal pain
  • Headache;
  • Itching;
  • A small nodule at the injection site;
  • Stomach upset
Interaction with insulin and insulin secretagogues when taken simultaneouslyYesYes
Interaction with other drugs
  • Diuretics – bumetanide, furosemide;
  • Cortisone and prednisolone;
  • Salmeterol;
  • Estrogen-containing drugs, including birth control and hormone substitutes.
Unique interactions with other drugs
  • Fenofibrate;
  • Antidepressants;
  • Disopyramide;
  • Ibuprofen, meloxicam, naproxen;
  • Clozapine;
  • Clarithromycin;
  • Captopril, enalapril, ramipril
Increased pancreatic cell growth promoting insulin secretionYesNo
Interaction with warfarinNoYes
It is the equivalent ofA substance produced by the human bodyA peptide found in the saliva of a rare lizard
Slow down digestionYesNo
Use as a “monotherapy”Used as a single medicineUsually used in combination with other medicines such as metformin or a sulfonylurea
Additional useNoAs a remedy for Parkinson’s disease
Dosage formInjection pensInjection pens or powder for suspension for subcutaneous injection


Ozempic and Bydureon are very similar drugs in their purpose and action.

But there are some key differences between them. The former is an analogue of a chemical substance produced by the human body. The latter is an analogue of a chemical substance produced by a lizard.

Ozempic is available as pre-filled injection pens. Bydureon is a powder mixed with a liquid (diluent) and injected immediately after mixing.

Ozempic has a weaker action. Bydureon is a stronger drug. Accordingly, its possible side effects are more pronounced.


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